EXTL2

Across TCGA patient cohorts, EXTL2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL2-associated genes across cancer lineages are MSH2, EGFR_pY1068, and FASN. Each is linked with EXTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXTL2-to-partner and partner-to-EXTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by EXTL2-low versus EXTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL2→partner) and Y-score (partner→EXTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.236	-3.295	.010	.009	3	2
UCEC	EGFR_pY1068 →	-0.245	-1.906	.015	.016	3	1
UCEC	FASN →	+0.494	+3.169	.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.109	-1.990	.030	.030	3	1
UCEC	IGFBP2 →	-0.686	-2.321	.008	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-1.893	.005	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MSH2 by EXTL2 expression — UCEC

Explore this box plot interactively →