EXTL1

Across TCGA patient cohorts, EXTL1 mutation is significantly associated with the RNA expression of many other genes, with 2,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL1-associated genes across cancer lineages are CCDC51, ATP5MGP6, and CST8. Each is linked with EXTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXTL1-to-partner and partner-to-EXTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC51 grouped by EXTL1-low versus EXTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL1→partner) and Y-score (partner→EXTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC51 →	+0.379	+2.343	.007	.003	3	3
LUAD	ATP5MGP6 →	+0.504	+3.708	<.001	.003	3	2
LGG	CST8 →	+0.036	+4.679	<.001	.007	3	2
SKCM	MIR3978 →	+0.446	+5.080	<.001	.004	3	2
SKCM	OR7E18P →	+0.060	+4.513	<.001	.009	3	2
SKCM	REG1CP →	+0.043	+4.680	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,832 associations by consensus.

CCDC51 by EXTL1 expression — UCEC

Explore this box plot interactively →