EXTL1

Across TCGA patient cohorts, EXTL1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL1-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and ATM. Each is linked with EXTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXTL1-to-partner and partner-to-EXTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by EXTL1-low versus EXTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL1→partner) and Y-score (partner→EXTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.156	-1.501	.006	.015	3	3
UCEC	PDCD4 →	-0.475	-1.700	.003	.040	3	3
UCEC	ATM →	-0.574	-3.893	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.587	+2.815	<.001	.036	3	2
UCEC	PCNA →	+0.207	+1.700	.004	.040	3	2
UCEC	XBP1 →	-0.147	-1.687	.002	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK_pT183_Y185 by EXTL1 expression — UCEC

Explore this box plot interactively →