EXTL1

Across TCGA cell cohorts, EXTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,238 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EXTL1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of mRNA splicing, via spliceosome. Each is linked with EXTL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both EXTL1-to-partner and partner-to-EXTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by EXTL1-low versus EXTL1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL1→partner) and Y-score (partner→EXTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of myoblast fusion →	+0.119	+0.411	<.001	.006	3	10
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.134	+0.227	<.001	.003	3	10
STOMACH	Regulation of mRNA splicing, via spliceosome →	+0.095	+0.243	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.101	+0.118	<.001	.003	3	9
STOMACH	Cytoplasmic translation →	+0.084	+0.417	<.001	.005	3	9
SKIN	Negative regulation of RNA splicing →	+0.062	+1.534	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,238 associations by consensus.

Negative regulation of myoblast fusion by EXTL1 expression — STOMACH

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