EXTL1

Across TCGA cell cohorts, EXTL1 mutation is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EXTL1-associated genes across cancer lineages are OR13C5, LRRD1, and DNAAF6. Each is linked with EXTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXTL1-to-partner and partner-to-EXTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C5 grouped by EXTL1-low versus EXTL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL1→partner) and Y-score (partner→EXTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR13C5 →	+0.011	+3.017	.001	.006	3	2
BLOOD_Leukemia	LRRD1 →	+0.083	+3.437	.003	.009	3	2
BLOOD_Leukemia	DNAAF6 →	+0.019	+2.432	.006	.006	3	2
BLOOD_Lymphoma	CCL8 →	+0.016	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	PRLHR →	+0.008	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	HBZ →	+0.197	+3.847	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

OR13C5 by EXTL1 expression — OVARY

Explore this box plot interactively →