EXT2

Across TCGA patient cohorts, EXT2 mutation is significantly associated with the RNA expression of many other genes, with 4,334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXT2-associated genes across cancer lineages are STX5, TCF3, and DNAJC11. Each is linked with EXT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXT2-to-partner and partner-to-EXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STX5 grouped by EXT2-low versus EXT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT2→partner) and Y-score (partner→EXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STX5 →	+0.290	+3.828	.003	<.001	3	3
UCEC	TCF3 →	+0.680	+2.191	<.001	<.001	3	3
UCEC	DNAJC11 →	+0.551	+1.893	<.001	<.001	3	3
UCEC	SNW1 →	+0.432	+2.191	.001	<.001	3	3
UCEC	DCPS →	+0.409	+2.180	.001	<.001	3	3
UCEC	EPS15L1 →	+0.361	+2.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,334 associations by consensus.

STX5 by EXT2 expression — UCEC

Explore this box plot interactively →