EXT2

Across TCGA patient cohorts, EXT2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXT2-associated genes across cancer lineages are p27_pT198, PRAS40_pT246, and Rad50. Each is linked with EXT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXT2-to-partner and partner-to-EXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by EXT2-low versus EXT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT2→partner) and Y-score (partner→EXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.094	+3.321	.014	.010	3	2
UCEC	PRAS40_pT246 →	+0.151	+1.807	.014	.025	3	2
UCEC	Rad50 →	-0.219	-2.446	.012	.018	3	2
UCEC	Annexin-1 →	+0.477	+2.341	.011	.019	3	2
UCEC	Tuberin_pT1462 →	+0.255	+1.512	.002	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.630	+2.341	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p27_pT198 by EXT2 expression — UCEC

Explore this box plot interactively →