EXT2

Across TCGA cell cohorts, EXT2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EXT2-associated genes across cancer lineages are RNASE8, CXCL13, and LRRC53. Each is linked with EXT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXT2-to-partner and partner-to-EXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by EXT2-low versus EXT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT2→partner) and Y-score (partner→EXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNASE8 →	+0.027	+3.345	.005	.007	3	2
BLOOD_Leukemia	CXCL13 →	+0.061	+3.857	<.001	.003	3	1
BLOOD_Leukemia	LRRC53 →	+0.012	+3.786	<.001	.002	3	1
BLOOD_Leukemia	NLGN4Y →	+0.740	+3.594	.007	.007	3	1
BLOOD_Leukemia	SCNN1G →	+0.101	+3.744	<.001	.003	3	1
BLOOD_Leukemia	TCERG1L →	+1.415	+3.744	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RNASE8 by EXT2 expression — LARGE_INTESTINE

Explore this box plot interactively →