EXT2

Across TCGA cell cohorts, EXT2 mutation is significantly associated with the mutation status of many other genes, with 1,991 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXT2-associated genes across cancer lineages are SLC45A3, RYK, and A2ML1. Each is linked with EXT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXT2-to-partner and partner-to-EXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC45A3 grouped by EXT2-low versus EXT2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT2→partner) and Y-score (partner→EXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC45A3 →	+4.392	+4.392	.009	.009	1	3
SKIN	RYK →	+5.392	+4.824	.004	.004	1	3
SKIN	A2ML1 →	+2.977	+4.392	.005	.005	1	3
SKIN	INSR →	+2.977	+4.392	.005	.005	1	3
SKIN	COL24A1 →	+2.977	+4.392	.005	.005	1	3
SKIN	CDH4 →	+3.392	+4.718	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,991 associations by consensus.

SLC45A3 by EXT2 expression — SKIN

Explore this box plot interactively →