EXT1

Across TCGA patient cohorts, EXT1 mutation is significantly associated with the RNA expression of many other genes, with 4,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXT1-associated genes across cancer lineages are GNL3, WDR41, and RAD18. Each is linked with EXT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXT1-to-partner and partner-to-EXT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNL3 grouped by EXT1-low versus EXT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT1→partner) and Y-score (partner→EXT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNL3 →	+0.370	+2.628	.003	<.001	3	3
UCEC	WDR41 →	+0.310	+1.688	.003	.001	3	3
UCEC	RAD18 →	+0.363	+2.628	<.001	<.001	3	3
SKCM	RRP9 →	+0.627	+3.964	<.001	<.001	3	3
BRCA	RNU1-14P →	+0.413	+6.382	<.001	.001	3	3
UCEC	CCDC43 →	+0.495	+1.939	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,157 associations by consensus.

GNL3 by EXT1 expression — UCEC

Explore this box plot interactively →