EXT1

Across TCGA patient cohorts, EXT1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXT1-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and JNK2. Each is linked with EXT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXT1-to-partner and partner-to-EXT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by EXT1-low versus EXT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT1→partner) and Y-score (partner→EXT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.307	+1.201	.012	.028	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-1.999	.001	.002	3	2
UCEC	JNK2 →	+0.215	+2.441	<.001	.001	3	2
UCEC	VEGFR2 →	+0.192	+1.415	.037	.040	3	2
UCEC	Caspase-7-cleavedD198 →	+0.669	+2.502	<.001	.001	3	2
UCEC	Caspase-8 →	-0.284	-2.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FASN by EXT1 expression — UCEC

Explore this box plot interactively →