EXT1

Across TCGA cell cohorts, EXT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,979 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible EXT1-associated GO terms across cancer lineages are Regulation of fibroblast proliferation, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, and Actin filament depolymerization. Each is linked with EXT1 in more than 12 cancer types. Because this analysis shows association rather than direction, both EXT1-to-partner and partner-to-EXT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibroblast proliferation grouped by EXT1-low versus EXT1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT1→partner) and Y-score (partner→EXT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of fibroblast proliferation →	+0.113	+1.412	<.001	<.001	3	13
BONE	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.070	+1.490	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.220	+1.644	.002	.001	3	13
BONE	Collagen fibril organization →	+0.272	+1.593	<.001	<.001	3	13
LIVER	Negative regulation of Rho protein signal transduction →	+0.173	+1.404	.001	.001	3	13
LIVER	Positive regulation of focal adhesion assembly →	+0.193	+1.345	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,979 associations by consensus.

Regulation of fibroblast proliferation by EXT1 expression — LUNG_SCLC

Explore this box plot interactively →