EXT1

Across TCGA cell cohorts, EXT1 mutation is significantly associated with the RNA expression of many other genes, with 553 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXT1-associated genes across cancer lineages are KRT37, ARGFX, and SEC24B. Each is linked with EXT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXT1-to-partner and partner-to-EXT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT37 grouped by EXT1-low versus EXT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT1→partner) and Y-score (partner→EXT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT37 →	+0.008	+4.247	<.001	.004	3	2
OVARY	ARGFX →	+0.035	+5.196	<.001	.005	3	2
LARGE_INTESTINE	SEC24B →	+0.681	+3.212	.001	.006	3	2
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	GPR17 →	+0.255	+3.584	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 553 associations by consensus.

KRT37 by EXT1 expression — BLOOD_Leukemia

Explore this box plot interactively →