EXPH5

Across TCGA cell cohorts, EXPH5 mutation is significantly associated with the RNA expression of many other genes, with 415 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXPH5-associated genes across cancer lineages are IL3, OR2A4, and PRAMEF14. Each is linked with EXPH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXPH5-to-partner and partner-to-EXPH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by EXPH5-low versus EXPH5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXPH5→partner) and Y-score (partner→EXPH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IL3 →	+0.020	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	OR2A4 →	+0.060	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	PRAMEF14 →	+0.090	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GSTT4 →	+0.013	+4.643	<.001	.008	3	2
SOFT_TISSUE	OR2T3 →	+1.787	+4.977	<.001	.002	3	2
BLOOD_Myeloma	OR52E6 →	+0.060	+3.514	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 415 associations by consensus.

IL3 by EXPH5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →