EXOSC9

Across TCGA patient cohorts, EXOSC9 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC9-associated genes across cancer lineages are FASN, mTOR_pS2448, and 14-3-3_beta. Each is linked with EXOSC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC9-to-partner and partner-to-EXOSC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by EXOSC9-low versus EXOSC9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC9→partner) and Y-score (partner→EXOSC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.308	+1.289	.014	.023	3	2
UCEC	mTOR_pS2448 →	-0.131	-1.986	.006	.008	3	2
UCEC	14-3-3_beta →	-0.069	-2.295	.031	.005	3	1
UCEC	EGFR_pY1068 →	-0.200	-1.523	.012	.008	3	1
UCEC	eIF4E →	+0.196	+3.598	.003	.001	3	1
UCEC	ERK2 →	+0.166	+1.523	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FASN by EXOSC9 expression — UCEC

Explore this box plot interactively →