EXOSC8

Across TCGA patient cohorts, EXOSC8 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC8-associated genes across cancer lineages are Notch1, PDCD4, and PKC-b-II_pS660. Each is linked with EXOSC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC8-to-partner and partner-to-EXOSC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by EXOSC8-low versus EXOSC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC8→partner) and Y-score (partner→EXOSC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.352	+3.013	<.001	.018	3	1
UCEC	PDCD4 →	-1.025	-3.169	<.001	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.339	-3.169	.025	.020	3	1
UCEC	Src →	+0.253	+3.169	.025	.020	3	1
UCEC	NF-kB-p65_pS536 →	-0.619	-2.990	.013	.036	2	1
UCEC	PCNA →	+0.348	+3.000	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by EXOSC8 expression — UCEC

Explore this box plot interactively →