EXOSC8

Across TCGA cell cohorts, EXOSC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,126 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EXOSC8-associated GO terms across cancer lineages are Establishment of meiotic spindle orientation, Positive regulation of mitotic sister chromatid separation, and U1 snRNA 3'-end processing. Each is linked with EXOSC8 in more than 16 cancer types. Because this analysis shows association rather than direction, both EXOSC8-to-partner and partner-to-EXOSC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of meiotic spindle orientation grouped by EXOSC8-low versus EXOSC8-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC8→partner) and Y-score (partner→EXOSC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Establishment of meiotic spindle orientation →	+0.215	+1.024	<.001	<.001	3	17
BONE	Positive regulation of mitotic sister chromatid separation →	+0.196	+0.989	.008	<.001	3	15
SOFT_TISSUE	U1 snRNA 3'-end processing →	+0.126	+1.347	<.001	<.001	3	15
SOFT_TISSUE	U5 snRNA 3'-end processing →	+0.126	+1.347	<.001	<.001	3	15
KIDNEY	Protein localization to kinetochore →	+0.204	+1.309	<.001	<.001	3	15
BREAST	Mitotic metaphase chromosome alignment →	+0.113	+0.691	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,126 associations by consensus.

Establishment of meiotic spindle orientation by EXOSC8 expression — KIDNEY

Explore this box plot interactively →