EXOSC7

Across TCGA pan-cancer cohorts, EXOSC7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EXOSC7 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EXOSC7 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EXOSC7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, COAD, and LUAD are the cancer types where EXOSC7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.916	.023	30	view →
COAD	DFS	Quartile	All	0.912	1.000	.047	6	view →
LUAD	OS	Median	II,III,IV	0.782	0.509	.023	5	view →
LSCC	DFS	Median	II,III,IV	0.848	0.559	.020	5	view →
PDAC	DFS	Median	III,IV	0.737	0.406	.045	2	view →
CCRCC	DFS	Quartile	All	0.563	0.978	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EXOSC7–UCEC (OS)

Open the UCEC breakdown →