EXOSC4

Across TCGA patient cohorts, EXOSC4 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC4-associated genes across cancer lineages are CD4+ memory T-cells, Mast cells, and Smooth muscle. Each is linked with EXOSC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC4-to-partner and partner-to-EXOSC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ memory T-cells grouped by EXOSC4-low versus EXOSC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC4→partner) and Y-score (partner→EXOSC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD4+ memory T-cells →	+0.043	+2.902	<.001	.034	3	1
UCEC	Mast cells →	+0.020	+3.042	.028	.018	2	1
UCEC	Smooth muscle →	+0.147	+3.010	.043	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD4+ memory T-cells by EXOSC4 expression — BLCA

Explore this box plot interactively →