EXOSC4

Across TCGA cell cohorts, EXOSC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,625 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EXOSC4-associated GO terms across cancer lineages are U4 snRNA 3'-end processing, Ribosome biogenesis, and Ribosome assembly. Each is linked with EXOSC4 in more than 17 cancer types. Because this analysis shows association rather than direction, both EXOSC4-to-partner and partner-to-EXOSC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U4 snRNA 3'-end processing grouped by EXOSC4-low versus EXOSC4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC4→partner) and Y-score (partner→EXOSC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	U4 snRNA 3'-end processing →	+0.199	+1.660	<.001	<.001	3	18
BONE	Ribosome biogenesis →	+0.101	+1.031	<.001	<.001	3	15
BONE	Ribosome assembly →	+0.085	+0.914	<.001	.001	3	14
BONE	Ribosomal large subunit biogenesis →	+0.106	+0.960	<.001	<.001	3	14
URINARY_TRACT	Maturation of SSU-rRNA →	+0.096	+0.991	.001	.001	3	13
LUNG_SCLC	rRNA pseudouridine synthesis →	+0.109	+0.823	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,625 associations by consensus.

U4 snRNA 3'-end processing by EXOSC4 expression — BONE

Explore this box plot interactively →