EXOSC3

Across TCGA pan-cancer cohorts, EXOSC3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EXOSC3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where EXOSC3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EXOSC3 is over-expressed in tumor.

LUAD, HNSC, and COAD are the cancer types where EXOSC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EXOSC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.184	<.001	8	view →
HNSC	Male	III,IV	+0.180	<.001	8	view →
COAD	Female	II,III,IV	+0.209	<.001	7	view →
LSCC	Male	II,III,IV	+0.232	<.001	5	view →
CCRCC	Male	All	+0.070	.015	4	view →
PDAC	Male	All	+0.320	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EXOSC3–LUAD

Open the LUAD breakdown →