EXOSC3

Across TCGA patient cohorts, EXOSC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,055 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible EXOSC3-associated proteins across cancer lineages are SMU1, GRHPR, and C9orf78. Each is linked with EXOSC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both EXOSC3-to-partner and partner-to-EXOSC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC3 versus SMU1 in GBM, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC3→partner) and Y-score (partner→EXOSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMU1 →	+0.230	+0.409	<.001	.001	3	6
HNSC	GRHPR →	+0.393	+0.586	<.001	<.001	3	6
COAD	C9orf78 →	+0.337	+0.565	<.001	<.001	3	6
GBM	IK →	+0.236	+0.343	<.001	<.001	3	6
GBM	APTX →	+0.312	+0.495	<.001	<.001	3	6
GBM	SPIN1 →	+0.478	+0.515	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,055 associations by consensus.

EXOSC3 vs SMU1 — GBM

Explore this scatter interactively →