EXOSC3

Across TCGA patient cohorts, EXOSC3 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC3-associated genes across cancer lineages are RN7SL134P, MIR548AI, and MIR4452. Each is linked with EXOSC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC3-to-partner and partner-to-EXOSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by EXOSC3-low versus EXOSC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC3→partner) and Y-score (partner→EXOSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.210	+3.277	<.001	.002	3	1
UCEC	MIR548AI →	+0.317	+4.928	<.001	.002	3	1
UCEC	MIR4452 →	+0.363	+4.069	<.001	.008	3	1
UCEC	FTLP5 →	+0.309	+3.861	<.001	.003	3	1
UCEC	H3Y2 →	+0.617	+3.370	.001	.001	3	1
UCEC	KRT18P14 →	+0.147	+2.942	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

RN7SL134P by EXOSC3 expression — UCEC

Explore this box plot interactively →