EXOSC3

Across TCGA patient cohorts, EXOSC3 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC3-associated genes across cancer lineages are mv Endothelial cells and lymphatic Endothelial cells. Each is linked with EXOSC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC3-to-partner and partner-to-EXOSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mv Endothelial cells grouped by EXOSC3-low versus EXOSC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC3→partner) and Y-score (partner→EXOSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mv Endothelial cells →	-0.029	-2.989	.036	.037	3	1
UCEC	lymphatic Endothelial cells →	-0.027	-2.946	.047	.037	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

mv Endothelial cells by EXOSC3 expression — UCEC

Explore this box plot interactively →