EXOSC3

Across TCGA cell cohorts, EXOSC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,116 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EXOSC3-associated GO terms across cancer lineages are U4 snRNA 3'-end processing, Interstrand cross-link repair, and DNA replication. Each is linked with EXOSC3 in more than 16 cancer types. Because this analysis shows association rather than direction, both EXOSC3-to-partner and partner-to-EXOSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U4 snRNA 3'-end processing grouped by EXOSC3-low versus EXOSC3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC3→partner) and Y-score (partner→EXOSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	U4 snRNA 3'-end processing →	+0.172	+1.071	<.001	.001	2	17
SOFT_TISSUE	Interstrand cross-link repair →	+0.085	+0.908	<.001	<.001	3	16
SOFT_TISSUE	DNA replication →	+0.113	+0.900	<.001	<.001	3	16
SOFT_TISSUE	DNA-templated DNA replication →	+0.136	+1.019	<.001	<.001	3	16
SOFT_TISSUE	DNA replication initiation →	+0.179	+0.797	<.001	<.001	3	16
BONE	Protein localization to chromosome →	+0.099	+0.716	.003	.006	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,116 associations by consensus.

U4 snRNA 3'-end processing by EXOSC3 expression — URINARY_TRACT

Explore this box plot interactively →