EXOSC2

Across TCGA patient cohorts, EXOSC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,134 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC2-associated proteins across cancer lineages are POLD1, RPL12_S38, and SMC2. Each is linked with EXOSC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both EXOSC2-to-partner and partner-to-EXOSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC2 versus POLD1 in LSCC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC2→partner) and Y-score (partner→EXOSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLD1 →	+0.329	+0.572	<.001	<.001	3	8
LSCC	RPL12_S38 →	+1.053	+0.699	<.001	<.001	3	8
LSCC	SMC2 →	+0.651	+0.701	<.001	<.001	3	8
LSCC	CHAF1B →	+0.554	+0.630	<.001	<.001	3	8
COAD	CTR9 →	+0.252	+0.520	<.001	<.001	3	8
LSCC	FEN1 →	+0.506	+0.630	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,134 associations by consensus.

EXOSC2 vs POLD1 — LSCC

Explore this scatter interactively →