EXOSC2

Across TCGA patient cohorts, EXOSC2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,923 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC2-associated genes across cancer lineages are RFC3, ANP32B, and DSCC1. Each is linked with EXOSC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both EXOSC2-to-partner and partner-to-EXOSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC2 versus RFC3 in GBM, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC2→partner) and Y-score (partner→EXOSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	+1.080	+0.326	<.001	<.001	3	7
HNSC	ANP32B →	+0.589	+0.146	<.001	<.001	3	6
BRCA	DSCC1 →	+0.958	+0.204	<.001	<.001	3	6
LSCC	UTP4 →	+0.518	+0.194	<.001	<.001	3	6
GBM	TYMS →	+0.910	+0.382	<.001	<.001	3	6
UCEC	OIP5 →	+0.835	+0.264	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,923 associations by consensus.

EXOSC2 vs RFC3 — GBM

Explore this scatter interactively →