EXOSC2

Across TCGA patient cohorts, EXOSC2 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC2-associated genes across cancer lineages are HBAP1, SSTR5, and EIF1AD. Each is linked with EXOSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC2-to-partner and partner-to-EXOSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBAP1 grouped by EXOSC2-low versus EXOSC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC2→partner) and Y-score (partner→EXOSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HBAP1 →	+0.230	+5.631	.003	.004	3	2
UCEC	SSTR5 →	+0.745	+3.286	<.001	.001	3	1
UCEC	EIF1AD →	+0.437	+3.223	.003	.009	3	1
UCEC	CDC6 →	+1.091	+3.212	<.001	.009	3	1
LUAD	OR52B1P →	+0.263	+5.631	<.001	.004	3	1
LUAD	OR7E103P →	+0.060	+5.343	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

HBAP1 by EXOSC2 expression — LUAD

Explore this box plot interactively →