EXOSC2

Across TCGA cell cohorts, EXOSC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,473 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EXOSC2-associated GO terms across cancer lineages are Regulation of chromosome condensation, Transcription by RNA polymerase I, and Immunoglobulin heavy chain V-D-J recombination. Each is linked with EXOSC2 in more than 19 cancer types. Because this analysis shows association rather than direction, both EXOSC2-to-partner and partner-to-EXOSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome condensation grouped by EXOSC2-low versus EXOSC2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC2→partner) and Y-score (partner→EXOSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of chromosome condensation →	+0.214	+1.283	<.001	<.001	3	20
BONE	Transcription by RNA polymerase I →	+0.153	+1.225	<.001	.001	3	20
KIDNEY	Immunoglobulin heavy chain V-D-J recombination →	+0.198	+0.615	<.001	<.001	3	20
BONE	DNA replication initiation →	+0.232	+1.303	<.001	<.001	3	19
BONE	Double-strand break repair →	+0.109	+1.386	<.001	<.001	3	19
PANCREAS	DNA-templated transcription elongation →	+0.078	+1.362	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,473 associations by consensus.

Regulation of chromosome condensation by EXOSC2 expression — PANCREAS

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