EXOSC10

Across TCGA patient cohorts, EXOSC10 protein abundance is significantly associated with the RNA expression of many other genes, with 14,599 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EXOSC10-associated genes across cancer lineages are PLK4, ORC6, and AUNIP. Each is linked with EXOSC10 in more than 6 cancer types. Because this analysis shows association rather than direction, both EXOSC10-to-partner and partner-to-EXOSC10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC10 versus PLK4 in GBM, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC10→partner) and Y-score (partner→EXOSC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLK4 →	+1.144	+0.413	<.001	<.001	3	7
GBM	ORC6 →	+1.005	+0.354	<.001	<.001	3	7
UCEC	AUNIP →	+0.761	+0.199	.001	<.001	3	6
COAD	LMOD1 →	-1.089	-0.155	.002	<.001	3	6
UCEC	CMAHP →	-0.750	-0.176	<.001	<.001	3	6
UCEC	FANCA →	+0.854	+0.263	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,599 associations by consensus.

EXOSC10 vs PLK4 — GBM

Explore this scatter interactively →