EXOSC10

Across TCGA patient cohorts, EXOSC10 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC10-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and PCNA. Each is linked with EXOSC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC10-to-partner and partner-to-EXOSC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EXOSC10-low versus EXOSC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC10→partner) and Y-score (partner→EXOSC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.218	-2.415	.030	.003	3	2
UCEC	p62 Lck ligand →	+0.306	+2.331	.019	.019	3	2
UCEC	PCNA →	+0.186	+2.415	.032	.003	3	2
UCEC	Rab25 →	-0.415	-1.906	.001	.016	3	2
UCEC	eIF4E →	+0.175	+3.459	.038	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-2.000	.010	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by EXOSC10 expression — UCEC

Explore this box plot interactively →