EXOSC10

Across TCGA cell cohorts, EXOSC10 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOSC10-associated genes across cancer lineages are PRND, SEL1L2, and ANKRD30BL. Each is linked with EXOSC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC10-to-partner and partner-to-EXOSC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRND grouped by EXOSC10-low versus EXOSC10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC10→partner) and Y-score (partner→EXOSC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.005	+3.874	.005	.005	3	2
OESOPHAGUS	SEL1L2 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	ANKRD30BL →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	OR13C2 →	+0.033	+4.906	<.001	.006	3	1
LARGE_INTESTINE	HMGXB4 →	+0.596	+3.067	.005	.009	3	1
LARGE_INTESTINE	HRK →	+0.616	+3.241	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PRND by EXOSC10 expression — BLOOD_Leukemia

Explore this box plot interactively →