EXOSC1

Across TCGA patient cohorts, EXOSC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,946 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC1-associated proteins across cancer lineages are WAPL, TIAL1, and CACUL1. Each is linked with EXOSC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both EXOSC1-to-partner and partner-to-EXOSC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC1 versus WAPL in GBM, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC1→partner) and Y-score (partner→EXOSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAPL →	+0.194	+0.372	<.001	<.001	3	7
GBM	TIAL1 →	+0.204	+0.423	.001	<.001	3	6
OV	CACUL1 →	+0.257	+0.347	<.001	.003	2	7
GBM	BTAF1 →	+0.229	+0.386	.001	.001	3	6
UCEC	CHUK →	+0.300	+0.384	<.001	<.001	3	6
OV	CWF19L1 →	+0.592	+0.648	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,946 associations by consensus.

EXOSC1 vs WAPL — GBM

Explore this scatter interactively →