EXOG

Across TCGA patient cohorts, EXOG mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOG-associated genes across cancer lineages are Ku80, MEK1, and PDCD4. Each is linked with EXOG in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOG-to-partner and partner-to-EXOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by EXOG-low versus EXOG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOG→partner) and Y-score (partner→EXOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.358	+3.335	.003	.005	3	1
UCEC	MEK1 →	+0.438	+2.999	.022	.035	3	1
UCEC	PDCD4 →	-0.502	-3.321	.042	.010	3	1
UCEC	C-Raf →	+0.231	+3.321	.002	.010	3	1
UCEC	Cyclin-B1 →	+0.739	+3.321	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by EXOG expression — UCEC

Explore this box plot interactively →