EXOG

Across TCGA cell cohorts, EXOG mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EXOG-associated genes across cancer lineages are MGAT4D, IFNG, and PTH2. Each is linked with EXOG in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOG-to-partner and partner-to-EXOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MGAT4D grouped by EXOG-low versus EXOG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOG→partner) and Y-score (partner→EXOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MGAT4D →	+0.023	+4.977	<.001	.007	3	1
CNS	IFNG →	+0.043	+5.321	.003	.005	3	1
CNS	PTH2 →	+0.120	+5.321	<.001	.005	3	1
CNS	ASB10 →	+0.062	+4.981	<.001	.008	3	1
CNS	UCMA →	+0.276	+5.754	<.001	.002	3	1
CNS	OR4D6 →	+0.142	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MGAT4D by EXOG expression — SKIN

Explore this box plot interactively →