EXOC6B

Across TCGA pan-cancer cohorts, EXOC6B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EXOC6B data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EXOC6B RNA is associated with better overall survival. In most high-consensus cancer types, elevated EXOC6B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, SCLC, and OV are the cancer types where EXOC6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.782	0.501	<.001	90	view →
SCLC	DFS	Median	All	0.726	0.389	<.001	83	view →
OV	OS	Median	All	0.277	0.365	.004	52	view →
MESO	DFS	Quartile	II,III,IV	0.302	0.546	.010	51	view →
KICH	OS	Tertile	All	0.676	1.000	.002	42	view →
LIHC	OS	Quartile	All	0.618	0.796	.006	14	view →
LGG	DFS	Median	All	0.870	0.777	.011	9	view →
LUSC	DFS	Tertile	II,III,IV	0.792	0.629	.018	9	view →
BLCA	DFS	Quartile	All	0.234	0.526	.019	6	view →
STAD	OS	Quartile	II,III,IV	0.369	0.663	.019	6	view →
CHOL	DFS	Tertile	III,IV	0.163	0.529	.024	6	view →
LUAD	DFS	Median	All	0.263	0.437	.008	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EXOC6B–KIRC (OS)

Open the KIRC breakdown →