EXOC6

Across TCGA pan-cancer cohorts, EXOC6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EXOC6 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EXOC6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EXOC6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where EXOC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.387	.003	58	view →
PDAC	DFS	Median	III,IV	0.917	0.513	.004	26	view →
LSCC	OS	Tertile	II,III,IV	0.969	0.606	.001	25	view →
OV	DFS	Median	All	0.654	1.000	.012	12	view →
GBM	DFS	Quartile	All	0.442	0.247	.022	5	view →
CCRCC	DFS	Tertile	III,IV	0.856	0.123	.036	4	view →
LUAD	DFS	Tertile	All	0.437	0.881	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EXOC6–UCEC (DFS)

Open the UCEC breakdown →