EXOC6

Across TCGA pan-cancer cohorts, EXOC6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EXOC6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where EXOC6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EXOC6 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, CCRCC, and COAD are the cancer types where EXOC6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EXOC6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.466	<.001	8	view →
CCRCC	Male	All	+0.161	<.001	6	view →
COAD	All	All	+0.144	.004	6	view →
PDAC	Female	All	−0.345	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

EXOC6–LSCC

Open the LSCC breakdown →