EXOC6

Across TCGA patient cohorts, EXOC6 mutation is significantly associated with the RNA expression of many other genes, with 4,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC6-associated genes across cancer lineages are PPP2R2D, CBARP, and MTND6P17. Each is linked with EXOC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXOC6-to-partner and partner-to-EXOC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by EXOC6-low versus EXOC6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC6→partner) and Y-score (partner→EXOC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP2R2D →	+0.464	+2.732	<.001	.003	3	3
UCEC	CBARP →	+0.617	+1.946	<.001	<.001	3	3
BRCA	MTND6P17 →	+0.050	+5.281	.002	.002	3	3
UCEC	ITGB1BP1 →	+0.270	+1.506	.004	.002	3	3
UCEC	RPL23AP7 →	+0.284	+1.485	.004	.003	3	3
UCEC	LIN7C →	+0.424	+1.785	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,249 associations by consensus.

PPP2R2D by EXOC6 expression — SKCM

Explore this box plot interactively →