EXOC6

Across TCGA patient cohorts, EXOC6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. COAD shows the largest number of these associations.

The most reproducible EXOC6-associated genes across cancer lineages are eIF4E, HER2, and INPP4B. Each is linked with EXOC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC6-to-partner and partner-to-EXOC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EXOC6-low versus EXOC6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC6→partner) and Y-score (partner→EXOC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.234	+2.597	<.001	.005	3	2
COAD	HER2 →	-0.553	-2.798	.004	.003	3	2
COAD	INPP4B →	-0.432	-1.874	.003	.047	3	2
COAD	PCNA →	+0.294	+1.749	.002	.049	3	2
COAD	PDCD4 →	-0.444	-2.106	.007	.018	3	2
COAD	TFRC →	+0.566	+1.610	.006	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eIF4E by EXOC6 expression — COAD

Explore this box plot interactively →