EXOC6

Across TCGA cell cohorts, EXOC6 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EXOC6-associated genes across cancer lineages are SPRR2F, SSX7, and MTRNR2L6. Each is linked with EXOC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC6-to-partner and partner-to-EXOC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR2F grouped by EXOC6-low versus EXOC6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC6→partner) and Y-score (partner→EXOC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPRR2F →	+0.275	+3.691	<.001	.002	3	2
LUNG_NSCLC_LUAD	SSX7 →	+0.022	+5.662	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
LUNG_SCLC	RTL3 →	+0.338	+4.817	<.001	.001	3	1
LUNG_SCLC	MAGEB3 →	+0.164	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

SPRR2F by EXOC6 expression — BLOOD_Leukemia

Explore this box plot interactively →