EXOC4

Across TCGA patient cohorts, EXOC4 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC4-associated genes across cancer lineages are A-Raf_pS299, PCNA, and ASNS. Each is linked with EXOC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXOC4-to-partner and partner-to-EXOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by EXOC4-low versus EXOC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC4→partner) and Y-score (partner→EXOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.114	-1.999	.001	.002	3	3
UCEC	PCNA →	+0.181	+1.321	.005	.012	3	3
COAD	ASNS →	+0.670	+3.008	.001	.019	3	3
BLCA	TFRC →	+0.759	+3.012	.001	.018	2	3
UCEC	ERK2 →	+0.168	+1.530	.003	.004	3	2
UCEC	ACC1 →	+0.219	+1.713	.046	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

A-Raf_pS299 by EXOC4 expression — UCEC

Explore this box plot interactively →