EXOC4

Across TCGA cell cohorts, EXOC4 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOC4-associated genes across cancer lineages are TTPA, WRAP53, and OXNAD1. Each is linked with EXOC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC4-to-partner and partner-to-EXOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTPA grouped by EXOC4-low versus EXOC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC4→partner) and Y-score (partner→EXOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTPA →	+1.035	+3.364	<.001	.002	3	2
LARGE_INTESTINE	WRAP53 →	+0.556	+3.364	.004	.002	3	2
LARGE_INTESTINE	OXNAD1 →	+0.485	+3.364	.002	.002	3	2
CNS	CDX4 →	+0.005	+4.035	<.001	.006	3	2
CNS	OR2W3 →	+1.154	+3.117	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	ATP1B4 →	+0.024	+4.129	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

TTPA by EXOC4 expression — LARGE_INTESTINE

Explore this box plot interactively →