Across TCGA pan-cancer cohorts, EXOC3L4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EXOC3L4 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher EXOC3L4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EXOC3L4 expression acts as an unfavorable survival marker.

TGCT, HNSC, and UCEC are the cancer types where EXOC3L4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Median	III,IV	0.003	1.000	<.001	36	view →
HNSC	OS	Median	All	0.196	0.751	.004	27	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: EXOC3L4 tumor-vs-normal RNA expression · all EXOC3L4 data types