EXOC3L1

Across TCGA patient cohorts, EXOC3L1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC3L1-associated genes across cancer lineages are 14-3-3_beta, Ku80, and p62 Lck ligand. Each is linked with EXOC3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC3L1-to-partner and partner-to-EXOC3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EXOC3L1-low versus EXOC3L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC3L1→partner) and Y-score (partner→EXOC3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.095	-2.973	.030	.035	3	1
UCEC	Ku80 →	+0.263	+2.009	.010	.017	3	1
UCEC	p62 Lck ligand →	+0.361	+3.469	.011	.002	3	1
UCEC	PDK1_pS241 →	+0.196	+2.321	.008	.034	3	1
UCEC	Tuberin →	+0.328	+3.321	.005	.009	3	1
UCEC	VHL →	-1.004	-2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

14-3-3_beta by EXOC3L1 expression — UCEC

Explore this box plot interactively →