EXOC3L1

Across TCGA cell cohorts, EXOC3L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,153 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EXOC3L1-associated GO terms across cancer lineages are Negative regulation of regulatory T cell differentiation, Antigen processing and presentation of peptide antigen via MHC class I, and Regulation of cytoplasmic pattern recognition receptor signaling pathway. Each is linked with EXOC3L1 in more than 11 cancer types. Because this analysis shows association rather than direction, both EXOC3L1-to-partner and partner-to-EXOC3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of regulatory T cell differentiation grouped by EXOC3L1-low versus EXOC3L1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC3L1→partner) and Y-score (partner→EXOC3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of regulatory T cell differentiation →	+0.176	+0.738	.002	.001	3	12
URINARY_TRACT	Antigen processing and presentation of peptide antigen via MHC class I →	+0.200	+0.616	.002	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.051	+0.596	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	CD8-positive, alpha-beta T cell homeostasis →	+0.132	+0.822	.001	.001	3	10
URINARY_TRACT	CD8-positive, alpha-beta T cell differentiation →	+0.108	+0.453	<.001	<.001	3	10
LUNG_NSCLC_LUAD	CD8-positive, alpha-beta T cell activation →	+0.121	+0.309	<.001	.002	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,153 associations by consensus.

Negative regulation of regulatory T cell differentiation by EXOC3L1 expression — URINARY_TRACT

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