EXOC3

Across TCGA patient cohorts, EXOC3 mutation is significantly associated with the RNA expression of many other genes, with 2,352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC3-associated genes across cancer lineages are GAMTP2, MTCO2P15, and NT5C1B-RDH14. Each is linked with EXOC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXOC3-to-partner and partner-to-EXOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAMTP2 grouped by EXOC3-low versus EXOC3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC3→partner) and Y-score (partner→EXOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GAMTP2 →	+0.066	+4.757	.001	.004	3	3
CESC	MTCO2P15 →	+0.050	+4.384	<.001	.008	3	3
BLCA	NT5C1B-RDH14 →	+0.022	+4.433	<.001	.007	3	3
UCEC	ANKRD37 →	+0.437	+1.736	.004	.007	3	2
UCEC	BNIP3P1 →	+0.317	+2.354	<.001	<.001	3	2
UCEC	KRTAP20-3 →	+0.043	+3.436	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

GAMTP2 by EXOC3 expression — CESC

Explore this box plot interactively →