EXOC3

Across TCGA patient cohorts, EXOC3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC3-associated genes across cancer lineages are ERK2, MEK1, and MSH6. Each is linked with EXOC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC3-to-partner and partner-to-EXOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by EXOC3-low versus EXOC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC3→partner) and Y-score (partner→EXOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.121	+2.115	.043	.016	3	2
UCEC	MEK1 →	+0.314	+1.736	.005	.006	3	2
UCEC	MSH6 →	-0.318	-1.678	.001	.019	3	2
UCEC	Annexin-1 →	+0.482	+2.522	.003	<.001	3	2
UCEC	Cyclin-B1 →	+0.422	+1.906	.015	.014	3	2
UCEC	Notch1 →	+0.101	+1.820	.021	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ERK2 by EXOC3 expression — UCEC

Explore this box plot interactively →