EXOC3

Across TCGA cell cohorts, EXOC3 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOC3-associated genes across cancer lineages are DBX2, PYDC2, and GHRHR. Each is linked with EXOC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC3-to-partner and partner-to-EXOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by EXOC3-low versus EXOC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC3→partner) and Y-score (partner→EXOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DBX2 →	+0.011	+3.562	<.001	.002	3	2
BLOOD_Lymphoma	PYDC2 →	+0.062	+3.925	<.001	.006	3	2
OESOPHAGUS	GHRHR →	+0.453	+4.906	<.001	.006	3	1
BLOOD_Myeloma	RETNLB →	+0.065	+4.285	<.001	.003	3	1
BLOOD_Myeloma	CLEC4D →	+0.019	+3.906	<.001	.009	3	1
BLOOD_Myeloma	FAM71B →	+0.123	+3.906	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

DBX2 by EXOC3 expression — LARGE_INTESTINE

Explore this box plot interactively →