EXOC1

Across TCGA cell cohorts, EXOC1 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOC1-associated genes across cancer lineages are DEFB133, UBQLN3, and IGFL1. Each is linked with EXOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC1-to-partner and partner-to-EXOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB133 grouped by EXOC1-low versus EXOC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC1→partner) and Y-score (partner→EXOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB133 →	+0.164	+5.813	<.001	<.001	3	2
BLOOD_Myeloma	UBQLN3 →	+0.026	+4.285	<.001	.003	3	1
BLOOD_Myeloma	IGFL1 →	+0.044	+3.906	<.001	.009	3	1
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	A3GALT2 →	+0.030	+4.191	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.405	+5.472	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

DEFB133 by EXOC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →